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Panotem 20 tablet: Each enteric coated tablet contains Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20 mg.
Panotem 40 tablet: Each enteric coated tablet contains Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 40 mg.

Pantoprazole (Panotem) is indicated where suppression of acid secretion is of therapeutic benet. Pantoprazole (Panotem) is registered for the following indications: -
• Peptic ulcer diseases (PUD)
• Gastro esophageal reux diseases (GERD)
• Treatment of ulcer resistant to H2 receptor antagonists (H2RAs)
• Treatment of ulcers induced by non-steroidal anti-inammatory drugs (NSAIDs)
• Gastrointestinal (GI) bleeding from stress or acid peptic diseases
• Eradication of Helicobacter pylori (in combination with antibiotics)
• Zollinger-Ellison syndrome
• Prophylaxis for acid aspiration syndrome during induction of anesthesia

The usual recommended adult oral dose is 40 mg given once daily, before breakfast. The duration of therapy is ranging from 2-8 weeks.
Duodenal Ulcers: Panotem 40 mg tablet, once daily for 2 to 4 weeks. Duodenal ulcer generally heals within 2 weeks.
Gastric ulcers: Panotem 40 mg tablet, once daily for 4 to 8 weeks. Gastric ulcer generally heals within 4 weeks.
Reux esophagitis: Panotem 40 mg tablet, once daily for 4 to 8 weeks. Reux esophagitis generally heals within 4 weeks of treatment.
In resistant ulcers: Panotem 40 mg tablet, once daily for 8 weeks.
Ulcers induced by NSAIDs: Panotem 40 mg tablet once daily, in patients receiving continuous treatment with NSAIDs. GI bleeding from stress or acid peptic diseases: Usual adult oral dosage, if required the dosage may be increased.
Eradication of Helicobacter pylori: Triple therapy of Panotem 40 mg twice daily in combination with appropriate antibiotic for one week achieved eradication rates of 90 to100%.
Zollinger-Ellison syndrome: Panotem 40 mg 4 tablets per day. Once control of acid secretion has been achieved, the dose should be gradually reduced to the
lowest eective dose that maintains acid control.
Prophylaxis for acid aspiration syndrome during induction of anesthesia: 1 or 2 Panotem 40 mg tablet should be given the evening before surgery and repeated again the morning of surgery.
Maintenance therapy :
Maintenance treatment should involve the lowest dose of the drug. Both 20 and 40 mg doses of Pantoprazole (Panotem) are safe and eective in maintaining patients with healed reux esophagitis and PUD in remission.

Elder patient: No problems with Pantoprazole have been encountered in clinical use in this patient group.
OR AS DIRECTED BY THE PHYSICIAN.

Potentially life-threatening eects: None has been reported with respect to Pantoprazole.
Severe or irreversible adverse eects: No serious adverse reactions have been described to date.
Symptomatic adverse eects: Headache (1.3%) and diarrhoea (1.5%) are the two commonest reported adverse events. It doesn't inuence renal, cardiovascular, respiratory, endocrine, cognitive or motor functions and no consistent change have been found in any biochemical or haematological parameters. Peripheral edema has occasionally been reported in female patients. Other side eects may include abdominal pain, dizziness, nausea, epigastric discomfort, atulence, skin rash, pruritus etc.

Panotem 20 tablet: Each box contains 5 x 10’s tablet in blister pack.
Panotem 40 tablet: Each box contains 5 x 10’s tablet in blister pack.




PRESCRIBING INFORMATION