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Clozema 0.05% cream: Each 10 gm cream contains Clobetasol Propionate BP 5 mg.
Clozema 0.05% ointment: Each 10 gm ointment contains Clobetasol Propionate BP 5 mg.

Clobetasol Propionate is a highly potent topical steroid. It has both local anti inflammatory and immunosuppressive activity. When given systemically it has standard  glucocorticoid activity and binds with high affinity to the glucocorticoid receptor. Clobetasol Propionate inhibits the adherence of neutrophils and monocyte-macrophages; to  the capillary endothelial cells of inflammed area. Clobetasol blocks the effect of macrophage migration inhibitory factor and decreases the activation of plasminogen to plasmin.

Clozema is indicated in:
1. Initial control of all forms of hyperacute eczema in all age groups. 2. Chronic hyperkeratotic eczema of the hands and feet and patches of chronic lichen simplex. 3. Chronic hyperkeratotic psoriasis of any area of the body. 4. Severe acute photosensitivity. 5. Acute contact Dermatitis 6. Hypertrophic lichen planus. 7. Localized bullious disorders. 8. Keloid scarring. 9. Pretibial myxedema. 10. Suppression of reaction after cryotherapy.  11. Vitiligo.

Apply sparingly to the affected area once or twice daily until improvement occurs, As with other highly active topical steroid preparations, therapy should be discontinued when control is achieved. If a longer course is necessary, it is recommended that treatment should not be continued for more than four weeks without the patient's condition being observed. Repeated short courses of Clozema may be used to control exacerbations. If continuous steroid treatment is necessary, a less potent preparation should be used. In very resistant lesions, especially where there is hyperkeratosis, the anti-inflammatory effect of Clozema can be enhanced, if necessary, by occluding the treatment area with polythene film. Only overnight occlusion is usually adequate to bring about a satisfactory response. Thereafter, improvement can usually be maintained by application without occlusion.

Provided the weekly dosage is less than 50g in adults, any pituitaryadrenal suppression is likely to be transient with a rapid return to normal values once the short course of steroid therapy has ceased. The same applies to children given proportionate dosage. Use of occlusive dressings increases the absorption of topical corticosteroids. Prolonged and intensive treatment with a highly active corticosteroid preparation may cause atrophic changes, such as thinning, striae and dilatation of the superficial blood vessels, particularly when occlusive dressings are used or where skin folds are involved.

Clobetasol Propionate should be avoided in pregnant women. Mothers using large amounts of the drug should be aware of potential excretion in milk.
Acute overdose is very unlikely to occur. However, in the case of chronic overdosage or misuse, the features of hypercorticism may appear and in this situation topical steroids should be discontinued.
Store in a cool and dry place, away from light. Keep out of reach of children.
Clozema cream: Each pack has a tube containing 10 gm of the cream.
Clozema ointment: Each pack has a tube containing 10 gm of the ointment.