Each 5 ml concentrated oral solution contains lactulose USP 3.35 gm.
2.Hepatic encephalopathy (Portal systemic encephalopathy): Hepatic coma
Initially Avolose solution may be given twice daily. In due course the dose should be adjusted according to the needs of the individual, but the following serves as a guide-
Starting dose: Adults: (including the elderly) - 15 ml twice daily. Children: 5 to 10 years - 10 ml twice daily. Children under 5 years - 5 ml twice daily. Babies under 1 year - 2.5 ml twice daily.
Avolose solution may, if necessary, be taken with water, fruit juice etc. Hepatic encephalopathy: Adults (including the elderly): Initially 30-50 ml three times a day. Subsequently adjust the dose to produce two or three soft stools each day. Children: No dosage recommended for this indication. Because of Lactulose's physiological mode of action it may take up to 48 hours before effects are obtained. However, clinical experience has shown that this medicament does exhibit a 'carry-over' effect, which may enable the patient to reduce the dose gradually over a period of time. A maintenance dose of 15 ml per day provides only 14 kilocalories and is therefore, unlikely to adversely affect diabetic patients.
During the first few days of treatment, meteorism and increased flatulence may occur. These symptoms usually disappear under continued therapy. Diarrhoea may occur especially when used higher dosages,e.g. during treatment of portal systemic encephalopathy. Dosage should then be adjusted to obtain two or three formed stool pei day.
Avolose 100 ml : Each bottle contains 100 ml concentrated oral solution with a measuring cup.
Avolose 200 ml : Each bottle contains 200 ml concentrated oral solution with a measuring cup.